Research Article Open Access

SCREENING OF FOOD ADDITIVES ON MODEL ORGANISM CAENORHABDITIS ELEGANS

Abstract

The usage of Food additives in high concentrations has deleterious effect on human health. Therefore a rapid method to determine the effect of these toxic chemicals is required. In the present study the toxicity of four food additives were evaluated on Caenorhabditis elegans model organism. The mortality after 24hr was adopted as the endpoint for toxicity testing. The LC50 data was calculated and dose responsive curves were obtained. The study revealed that the toxicity was in order of Tannic Acid>Propyl gallate>Thiourea >Monosodium glutamate. The LC50 values were then compared with published data of LD50 of rats and mice using Spearman Rank correlation method .The data obtained showed a high positive correlation of toxicity of food additives in C.elegans with rats and mice and hence we demonstrate C.elegans as a suitable model organism for toxicity testing.

SURJO PRABHA PAUL AND SEEBA MANOJ

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